EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.66 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.66 | cerebellar Purkinje cell | restricted to the Purkinje cell soma and their dendrites in the molecular layer | Mus musculus | - |
3.1.3.66 | cerebellum | - |
Mus musculus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.66 | inositol polyphosphate 4-phosphatase type I | - |
Mus musculus |
3.1.3.66 | INPP4A | - |
Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
3.1.3.66 | Mus musculus | expression of INPP4A is uniform across the cerebellum and the Purkinje cells | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.66 | malfunction | Inpp4a weeble mutant has a frame shift mutation in Inpp4a and is characterized by an early onset recessive cerebellar ataxia. In the Inpp4a weeble mutant, Purkinje cells are lost in a specific temporal and spatial pattern: Purkinje cells are lost at early perinatal timepoints. Prior to the appearance of climbing fibers in the developing molecular layer, the Inpp4a weeble mutant has a normal complement of Purkinje cells and they are properly positioned, degeneration and reactive gliosis are present at postnatal day 5 and progress rapidly in a defined pattern of patches. Purkinje cell loss in the Inpp4awbl mutant is due to glutamate excitotoxicity initiated by the climbing fiber, whereby Eaat4 may exert a protective effect | Mus musculus |